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KMID : 0369319920120010025
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Allergy
1992 Volume.12 No. 1 p.25 ~ p.34
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The Effect of Allergen Bronchial Challenge to the Non-Specific Bronchial Hyperresponsiveness
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Abstract
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Bronchial hyperresponsiveness is a fundamental characteristics in bronchial asthma. The pathogenesis of bronchial hyperresponsivenss has not been clearly understood yet.
We studied non-specific brochial hyperresponsiveness with methacholine inhalation sequentially after allergen provocation in dust mite sensitive allergic asthma and/or allergic rhinitis to investigate if there is any relation between allergen
exposure
and brochial hyperresponsiveness.
5 of 22 study subjects showed early asthmatic reaction, but 17 of them showed late (dual) asthmatic reaction.
Non-specific brochial hyperresponsiveness was not increased in early asthmatic responder, however, it was increased in 13 of 17 late asthmatic responder.
The rest 4 of 17 late asthmatic responder whose bronchial reactivity had been increased enough(PC20-methacholine lower than 1.1mg/ml) already before allergen inhalation showed no increase in non-specific bronchial hyperresponsiveness after
allergen
provocation, so that no more increase of brochial hyperresponsiveness occurs in allergen induced late asthmatic reation when allergic inflamation has progressed enough already before allergen exposure.
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KEYWORD
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